DNA Methylation Biomarker Discovery for Colorectal Cancer Diagnosis Assistance Through Integrated Analysis.

Yi-Hsuan Tsai¹, Yi-Husan Lai², Shu-Jen Chen², Yi-Chiao Cheng³, Tun-Wen Pai¹

¹Department of Computer Science and Information Engineering, National Taipei University of Technology, Taipei, Taiwan.

²Department of Product Development, ACT Genomics Co., Ltd., Taipei, Taiwan.

³Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

PubMed PMC DOI PDF

Abstract

OBJECTIVE: This study aimed to identify biomarkers for colorectal cancer (CRC) with representative gene functions and high classification accuracy in tissue and blood samples. METHODS: We integrated CRC DNA methylation profiles from The Cancer Genome Atlas and comorbidity patterns of CRC to select biomarker candidates. We clustered these candidates near the promoter regions into multiple function…

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