Peer-Reviewed Publication
Am J Transplant2025;25(8):1775-1783.August 1, 2025Journal Article
Longitudinal assessment of the effect of invasive fungal infections on transplant success in kidney transplant recipients.
Lucy X Li1, Jiashu Xue2, Teresa Po-Yu Chiang3, Na Lu2, Darin Ostrander2, Sean X Zhang4, John W Baddley2, Shmuel Shoham2, Daniel C Brennan2, Christine M Durand2, William A Werbel2, Kieren A Marr5, Robin K Avery2, Nitipong Permpalung6
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: lli101@jh.edu.
2Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
3Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Center for Surgical and Transplant Applied Research, New York University Grossman School of Medicine, New York, New York, USA.
4Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
5Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Elion Therapeutics, New York, New York, USA; Pearl Diagnostics, Baltimore, Maryland, USA.
6Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Abstract
Invasive fungal infections (IFIs) significantly impact morbidity and mortality in kidney transplant recipients (KTRs), but their effect on allograft function remains poorly defined. This retrospective study examined adult KTRs transplanted at Johns Hopkins from 2012 to 2018, with follow-up through 2023. The association of IFIs with a composite outcome of graft failure and mortality was assessed us…
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