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Peer-Reviewed Publication
Obesity (Silver Spring)2025;33(4):632-658.April 1, 2025Journal Article

Weight-loss interventions for adolescents with Down syndrome: a systematic review.

Thessa I M Hilgenkamp1, Emily Davidson2, Keith M Diaz3, Richard Fleming4, Rachel Foster Kirk5, Mary Hastert6, Judy Kim7, Sarah Mann8, John Usseglio9, Andrea Videlefsky10, Lauren Ptomey6
1Department of Physical Therapy, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.
2Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
3Department of Medicine, Columbia University Medical Center, New York, New York, USA.
4Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, Massachusetts, USA.
5Hinge Health, San Francisco, California, USA.
6Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
7People's Community Clinic, Austin, Texas, USA.
8Mann Method Physical Therapy and Fitness, Arvada, Colorado, USA.
9Augustus C. Long Health Sciences Library, Columbia University Medical Center, New York, New York, USA.
10Adult Disability Medical Healthcare Clinic, Atlanta, Georgia, USA.

Abstract

OBJECTIVE: Youth with Down syndrome (DS) experience high rates of overweight and obesity; therefore, weight-loss interventions are warranted. We aimed to systematically review weight-loss interventions for adolescents with DS to better understand the most effective strategies and identify the current gaps in the literature. METHODS: This systematic review followed Preferred Reporting Items for Sy…

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