Peer-Reviewed Publication
Nat Med2025;31(4):1286-1293.April 1, 2025Journal Article
Artificial intelligence for individualized treatment of persistent atrial fibrillation: a randomized controlled trial.
Isabel Deisenhofer1, Jean-Paul Albenque2, Sonia Busch3, Edouard Gitenay4, Stavros E Mountantonakis5, Antoine Roux6, Jerome Horvilleur7, Babe Bakouboula8, Saumil Oza9, Selim Abbey10, Guillaume Theodore11, Antoine Lepillier12, Yves Guyomar13, Francis Bessiere14, Jaap Jan Smit15, Theophile Mohr Durdez16, Paola Milpied16, Anthony Appetiti16, Daniel Guerrero16, Tom De Potter17, Christian De Chillou18, Seth Goldbarg19, Atul Verma20, John D Hummel21,
1Department of Electrophysiology, German Heart Center Munich, Technical University of Munich (TUM) School of Medicine and Health, Munich, Germany. deisenhofer@dhm.mhn.de.
2Clinique Pasteur, Toulouse, France.
3Department of Electrophysiology, Herz-Zentrum Bodensee, Constance, Germany.
4Hopital Saint Joseph, Marseille, France.
5Northwell Health, New York, NY, USA.
6Pôle Santé République, Clermont-Ferrand, France.
7Hôpital Privé Jacques Cartier, Massy, France.
8Clinique Rhena, Strasbourg, France.
9Ascension St. Vincent's Riverside Hospital, Jacksonville, FL, USA.
10Hôpital privé Le Confluent, Nantes, France.
11Clinique Saint George, Nice, France.
12Centre Cardiologique du Nord, Saint-Denis, France.
13Hôpital Saint Philibert, Lomme, France.
14Hopital Cardiologique Louis Pradel, Institut Cardiologique de Lyon, Hospices Civils de Lyon, Lyon, France.
15Isala Klinieken, Zwolle, The Netherlands.
16Volta Medical, Marseille, France.
17Cardiovascular Center, Onze Lieve Vrouwziekenhuis Hospital, Aalst, Belgium.
18Département de Cardiologie, CHU de Nancy, Nancy, France.
19Division of Cardiology, New York-Presbyterian Queens, New York, NY, USA.
20McGill University Health Centre, Montreal, Quebec, Canada.
21The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Abstract
Although pulmonary vein isolation (PVI) has become the cornerstone ablation procedure for atrial fibrillation (AF), the optimal ablation procedure for persistent and long-standing persistent AF remains elusive. Targeting spatio-temporal electrogram dispersion in a tailored procedure has been suggested as a potentially beneficial alternative to a conventional PVI-only procedure. In this multicenter…
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