Health AI Central
Peer-Reviewed Publication
J Biomed Inform2025;162104761.February 1, 2025Journal Article

ARCH: Large-scale knowledge graph via aggregated narrative codified health records analysis.

Ziming Gan1, Doudou Zhou2, Everett Rush3, Vidul A Panickan4, Yuk-Lam Ho5, George Ostrouchovm3, Zhiwei Xu6, Shuting Shen7, Xin Xiong8, Kimberly F Greco8, Chuan Hong7, Clara-Lea Bonzel4, Jun Wen9, Lauren Costa5, Tianrun Cai10, Edmon Begoli3, Zongqi Xia11, J Michael Gaziano12, Katherine P Liao10, Kelly Cho12, Tianxi Cai13, Junwei Lu14
1Department of Statistics, University of Chicago, 5801 S Ellis Ave, Chicago, 60615, IL, USA.
2Department of Statistics and Data Science, National University of Singapore, 117546, Singapore.
3Oak Ridge national Laboratory, Bethel Valley Rd, Oak Ridge, 37830, TN, USA.
4Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA; VA Boston Healthcare System, 150 S Huntington Ave, Boston, 02130, MA, USA.
5VA Boston Healthcare System, 150 S Huntington Ave, Boston, 02130, MA, USA.
6Department of Statistics, University of Michigan, 500 S State St, Ann Arbor, 48109, MI, USA.
7Department of Biostatistics & Bioinformatics, Duke University, 1121 West Main St, Durham, 27708, NC, USA.
8Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, 02115, MA, USA.
9Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA.
10VA Boston Healthcare System, 150 S Huntington Ave, Boston, 02130, MA, USA; Brigham and Women's Hospital, 60 Fenwood Rd, Boston, 02115, MA, USA.
11Clinical and Translational Science, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, 15260, PA, USA.
12Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA; VA Boston Healthcare System, 150 S Huntington Ave, Boston, 02130, MA, USA; Brigham and Women's Hospital, 60 Fenwood Rd, Boston, 02115, MA, USA.
13Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA; VA Boston Healthcare System, 150 S Huntington Ave, Boston, 02130, MA, USA; Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, 02115, MA, USA.
14VA Boston Healthcare System, 150 S Huntington Ave, Boston, 02130, MA, USA; Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, 02115, MA, USA. Electronic address: junweilu@hsph.harvard.edu.
PubMed PMC DOI PDF

Abstract

OBJECTIVE: Electronic health record (EHR) systems contain a wealth of clinical data stored as both codified data and free-text narrative notes (NLP). The complexity of EHR presents challenges in feature representation, information extraction, and uncertainty quantification. To address these challenges, we proposed an efficient Aggregated naRrative Codified Health (ARCH) records analysis to generat…

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