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Peer-Reviewed Publication
Methods Mol Biol2025;2887185-196.January 1, 2025Journal Article

Structural Dynamics of SNARE Complex Assembly in the Ribbon Synapses Observed by smFRET.

Alexa L Andrzejewski1, Joshua Ferrar2, Marla Kratzer-Charron1, Mark E Bowen3, Ucheor B Choi1
1Quantum-Si, Guilford, CT, USA.
2Department of Biochemistry, University of West Virginia, Morgantown, WV, USA.
3Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA.
PubMed PMC DOI PDF

Abstract

Single-molecule fluorescence resonance energy transfer (smFRET) is a powerful technique for studying the structural dynamics of protein molecules or detecting interactions between protein molecules in real time. Due to the high sensitivity in spatial and temporal resolution, smFRET can decipher sub-populations within heterogeneous native state conformations, which are generally lost in traditional…

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