Peer-Reviewed Publication
PLoS One2025;20(1):e0317303.January 1, 2025Journal Article
Sex-specific associations of serum testosterone with gray matter volume and cerebral blood flow in midlife individuals at risk for Alzheimer's disease.
Matilde Nerattini1,2, Schantel Williams1, Caroline Andy3, Caroline Carlton1, Camila Zarate1, Camila Boneu1, Francesca Fauci1, Trisha Ajila1, Steven Jett1, Michael Battista1, Silky Pahlajani1,4, Valentina Berti2, Randolph Andrews5, Dawn C Matthews5, Jonathan P Dyke4, Roberta Diaz Brinton6, Lisa Mosconi1,4
1Department of Neurology, Weill Cornell Medicine, New York, NY, United States of America.
2Department of Experimental and Clinical Biomedical Sciences, Nuclear Medicine Unit, University of Florence, Florence, Italy.
3Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States of America.
4Department of Radiology, Weill Cornell Medicine, New York, NY, United States of America.
5ADM Diagnostics, Chicago, IL, United States of America.
6Department of Neurology and Pharmacology, University of Arizona, Tucson, AZ, United States of America.
Abstract
Testosterone, an essential sex steroid hormone, influences brain health by impacting neurophysiology and neuropathology throughout the lifespan in both genders. However, human research in this area is limited, particularly in women. This study examines the associations between testosterone levels, gray matter volume (GMV) and cerebral blood flow (CBF) in midlife individuals at risk for Alzheimer's…
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