Cyclodextrin-based iodophors with high iodine retention in solid state and in dilute solutions.

Fabiola Spitaleri¹, Sandro Dattilo², Danilo Aleo³, Maria Grazia Saita¹, Angela Patti⁴

¹MEDIVIS, Via Carnazza 34 C, I- 95030 Tremestieri Etneo, Catania, Italy.

²CNR - Istituto per i Polimeri, Compositi e Biomateriali, Via Paolo Gaifami 18, I-95126 Catania, Italy.

³MEDIVIS, Via Carnazza 34 C, I- 95030 Tremestieri Etneo, Catania, Italy. Electronic address: danilo.aleo@medivis.it.

⁴CNR - Istituto di Chimica Biomolecolare, Via Paolo Gaifami 18, I-95126 Catania, Italy. Electronic address: angela.patti@cnr.it.

PubMed DOI

Abstract

Iodine is a broad-spectrum antiseptic with the advantage of not inducing bacterial resistance, but its use is limited by volatility. This issue can be overcome by using "iodophors", which are molecular systems able to retain iodine and provide its sustained release. Cyclodextrins have proven effective in stabilizing iodine in solution through the formation of complexes, the preparation of which in…

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