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Pathogens2024;13(11)November 8, 2024Journal Article

Survival of Borrelia burgdorferi Strain B31 in Human Serum Is Not Dependent on C4BP Binding to the Bacterial Surface.

Tobias Jakobsson1,2, Pär Comstedt3, Sven Bergström2,4, Johan Normark1,2
1Department of Clinical Microbiology, Umeå University, 901 87 Umeå, Sweden.
2UCMR, Umeå Centre for Microbial Research, 901 87 Umeå, Sweden.
3Evaxion Biotech, Dr. Neergaards vej 5F, 2970 Hørsholm, Denmark.
4Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
PubMed PMC DOI PDF

Abstract

Lyme disease is a vector-borne illness caused by spirochetes belonging to the Borrelia burgdorferi species group. These bacteria employ several mechanisms to survive within the vertebrate host, including evasion of the complement system. In this study, we examine the protection against human serum killing by the binding of host complement regulators C4b-binding protein (C4BP) and factor H (FH) to…

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