Association of coronary inflammation with plaque vulnerability and fractional flow reserve in coronary artery disease.

You-Jung Choi¹, Seokhun Yang², Henry West³, Pete Tomlins⁴, Masahiro Hoshino⁵, Tadashi Murai⁵, Doyeon Hwang², Eun-Seok Shin⁶, Joon-Hyung Doh⁷, Chang-Wook Nam⁸, Jianan Wang⁹, Hitoshi Matsuo¹⁰, Tsunekazu Kakuta⁵, Charalambos Antoniades⁴, Bon-Kwon Koo¹¹

¹Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea; Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea.

²Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea.

³Acute Multidisciplinary Imaging and Interventional Centre, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Sydney Medical School, University of Sydney, Sydney, Australia; Caristo Diagnostics LTD, Oxford, United Kingdom.

⁴Acute Multidisciplinary Imaging and Interventional Centre, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

⁵Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.

⁶Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea; Korea and Division of Cardiology, Ulsan Hospital, Ulsan, South Korea.

⁷Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea.

⁸Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.

⁹Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

¹⁰Department of Cardiology, Gifu Heart Center, Gifu, Japan.

¹¹Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea; Institute on Aging, Seoul National University, Seoul, South Korea. Electronic address: bkkoo@snu.ac.kr.

PubMed DOI

Abstract

BACKGROUND: The fat attenuation index (FAI) measured using coronary computed tomography angiography (CCTA) enables the direct evaluation of pericoronary adipose tissue composition and vascular inflammation. We aimed to investigate the association of fractional flow reserve (FFR) and plaque vulnerability with coronary inflammation. METHODS: Patients with suspected coronary artery disease (CAD) who…

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Mentioned Companies

Caristo Diagnostics
affiliation

MeSH Terms

Humans0Fractional Flow Reserve, Myocardial*Male0Female0Plaque, Atherosclerotic*Coronary Artery Disease*Aged0Computed Tomography Angiography*Middle Aged0Coronary Angiography*Predictive Value of Tests0Coronary Vessels*Prognosis0Risk Factors0Time Factors0Risk Assessment0Retrospective Studies0Adiposity0Rupture, Spontaneous0Inflammation*

Keywords

Coronary artery diseaseCoronary computed coronary angiographyCoronary plaqueFat attenuation indexPhysiologic stenosis

Article Info

PMID: 39488477
DOI: 10.1016/j.jcct.2024.10.013
Received: June 6, 2024
Accepted: October 22, 2024

How to Cite

Choi YJ et al. Association of coronary inflammation with plaque vulnerability and fractional flow reserve in coronary artery disease. J Cardiovasc Comput Tomogr2025;19(1):32-39. doi:10.1016/j.jcct.2024.10.013

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