Peer-Reviewed Publication
Aging (Albany NY)2024;16(20):12955-12976.October 16, 2024Journal Article
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
Yu-Xuan Lyu1,2, Qiang Fu3,4,5, Dominika Wilczok6,7, Kejun Ying8, Aaron King9, Adam Antebi2,10, Aleksandar Vojta11, Alexandra Stolzing12, Alexey Moskalev13, Anastasia Georgievskaya14, Andrea B Maier15, Andrea Olsen16, Anja Groth17, Anna Katharina Simon18,19, Anne Brunet20, Aisyah Jamil21, Anton Kulaga22,23, Asif Bhatti24, Benjamin Yaden25, Bente Klarlund Pedersen26, Björn Schumacher27, Boris Djordjevic28,29, Brian Kennedy15, Chieh Chen30,31, Christine Yuan Huang32, Christoph U Correll33,34, Coleen T Murphy35,36, Collin Y Ewald37, Danica Chen38,39,40, Dario Riccardo Valenzano41, Dariusz Sołdacki42, David Erritzoe43, David Meyer27, David A Sinclair44, Eduardo Nunes Chini45, Emma C Teeling46, Eric Morgen47, Eric Verdin48, Erik Vernet49, Estefano Pinilla50, Evandro F Fang51, Evelyne Bischof52, Evi M Mercken53, Fabian Finger54, Folkert Kuipers55, Frank W Pun56, Gabor Gyülveszi57, Gabriele Civiletto58, Garri Zmudze59, Gil Blander60, Harold A Pincus61, Joshua McClure62, James L Kirkland63, James Peyer64, Jamie N Justice65, Jan Vijg66, Jennifer R Gruhn67, Jerry McLaughlin68, Joan Mannick69, João Passos70, Joseph A Baur71, Joe Betts-LaCroix72, John M Sedivy73, John R Speakman74, Jordan Shlain75, Julia von Maltzahn76, Katrin I Andreasson77, Kelsey Moody78, Konstantinos Palikaras79, Kristen Fortney47, Laura J Niedernhofer80, Lene Juel Rasmussen81, Liesbeth M Veenhoff55, Lisa Melton82, Luigi Ferrucci83, Marco Quarta84,85,86, Maria Koval87, Maria Marinova88, Mark Hamalainen89, Maximilian Unfried15,90, Michael S Ringel91, Milos Filipovic92, Mourad Topors93, Natalia Mitin94, Nawal Roy95, Nika Pintar96, Nir Barzilai97, Paolo Binetti50, Parminder Singh48, Paul Kohlhaas98, Paul D Robbins99, Paul Rubin47, Peter O Fedichev100, Petrina Kamya101, Pura Muñoz-Canoves102, Rafael de Cabo103, Richard G A Faragher104, Rob Konrad105, Roberto Ripa2, Robin Mansukhani106, Sabrina Büttner107, Sara A Wickström108, Sebastian Brunemeier109, Sergey Jakimov59, Shan Luo110, Sharon Rosenzweig-Lipson68, Shih-Yin Tsai111, Stefanie Dimmeler112, Thomas A Rando113, Tim R Peterson114, Tina Woods115,116, Tony Wyss-Coray77, Toren Finkel117, Tzipora Strauss118,119, Vadim N Gladyshev8, Valter D Longo120, Varun B Dwaraka121, Vera Gorbunova122, Victoria A Acosta-Rodríguez123, Vincenzo Sorrentino15, Vittorio Sebastiano124, Wenbin Li125, Yousin Suh126, Alex Zhavoronkov21, Morten Scheibye-Knudsen81, Daniela Bakula81
1Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
2Max Planck Institute for Biology of Ageing, Cologne, Germany.
3Institute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China.
4Anti-aging Innovation Center, Subei Research Institute at Shanghai Jiaotong University, China.
5Shandong Cellogene Pharmaceutics Co. LTD, Yantai, China.
6Duke Kunshan University, Kunshan, Jiangsu, China.
7Duke University, Durham, NC, USA.
8Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA.
9Foresight Institute, San Francisco, CA 91125, USA.
10Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
11Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
12Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
13Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia.
14HautAI OÜ, Tallinn, Estonia.
15Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
16California Institute of Technology, Pasadena, CA 91125, USA.
17Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
18Max Delbrück Center for Molecular Medicine, Berlin, Germany.
19The Kennedy Institute of Rheumatology, Oxford, UK.
20Department of Genetics, Stanford University, Stanford, CA 94305, USA.
21Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE.
22Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
23Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany.
24America's Frontier Fund, VA 23320, USA.
25Department of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University - Purdue University Indianapolis, Indianapolis Indiana 46077, USA.
26Centre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark.
27Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany.
28199 Biotechnologies Ltd., London, UK.
29University College London, London, UK.
30Molecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA.
31Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
32Hong Kong Quantum AI Lab, Hong Kong.
33Zucker School of Medicine at Hofstra/Northwell, NY 10001, USA.
34Charité - University Medicine, Berlin, Germany.
35Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
36Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
37Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland.
38Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
39Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
40Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
41Leibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany.
42Longevity Center Europe, Warsaw, Poland.
43Centre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK.
44Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA.
45Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA.
46School of Biology and Environmental Science, Belfield, Univeristy College Dublin, Dublin 4, Ireland.
47BioAge Labs, Richmond, CA 94530, USA.
48Buck Institute for Research on Aging, Novato, CA 94945, USA.
49Research and Early Development, Maaleov 2760, Denmark.
50VitaDAO, Ottawa, ON K1V 9K6, Canada.
51Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
52Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
53Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark.
54Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark.
55European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
56Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China.
57Rejuveron Life Sciences AG, 8952 Schlieren, Switzerland.
58Health, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland.
59LongeVC, Riga, Latvia.
60InsideTracker, Cambridge, MA 02114, USA.
61Department of Psychiatry, Columbia University, New York, NY 10012, USA.
62Maxwell Biosciences, Austin, TX 73301, USA.
63Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
64Cambrian Bio, Inc., New York, NY 10012, USA.
65XPRIZE Foundation, Culver City, CA 90230, USA.
66Department of Genetics Albert Einstein College of Medicine, New York, NY 10461, USA.
67Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
68Life Biosciences, Boston, MA 02116, USA.
69Tornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA.
70Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
71Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA.
72Retro Biosciences, Inc., Redwood City, CA 94061, USA.
73Center on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA.
74Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
75Private Medical, San Francisco, CA 94107, USA.
76Faculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany.
77Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
78Ichor Life Sciences, Inc., LaFayette, NY 13084, USA.
79Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
80Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA.
81Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
82Nature Biotechnology, Springer Nature, London, UK.
83Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA.
84Rubedo Life Sciences, Sunnyvale, CA 94043, USA.
85Turn Biotechnologies, Mountain View 94039, CA, USA.
86Phaedon Institute, Oakland, CA 94501, USA.
87Institute of Biochemistry of the Romanian Academy, Romania.
88Fertility and Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
89Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA.
90Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore.
91Boston Consulting Group, Boston, MA 02210, USA.
92Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany.
93Repair Biotechnologies, Inc., Syracuse, NY 13210, USA.
94Sapere Bio, Triangle Research Park, NC 27213, USA.
95Holmusk, New York, NY 10012, USA.
96AniBiome, Zagreb, Croatia.
97Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA.
98Molecule, Neuhausen am Rheinfall, Switzerland.
99Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA.
100Gero PTE, Singapore, Singapore.
101Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8 Canada.
102Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA.
103Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, Maryland 21201, USA.
104Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK.
105Biolytica, Zug, Switzerland.
106Deciduous Therapeutics, San Francisco, CA 94107, USA.
107Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden.
108Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
109Healthspan Capital, El Cerrito, CA 94530, USA.
110School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
111Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
112Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany.
113Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
114Bioio, Inc., St. Louis, MO 63110, USA.
115Collider Heath, London, UK.
116Healthy Longevity Champion, National Innovation Centre for Ageing, UK.
117Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA.
118Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel.
119Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
120Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA.
121TruDiagnostic, Lexington, KY 40503, USA.
122Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.
123Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
124Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA.
125Department of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
126Department of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA.
Abstract
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial int…
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