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Intensive Care Med2024;50(12):2094-2104.December 1, 2024Journal Article

Distinct immune profiles and clinical outcomes in sepsis subphenotypes based on temperature trajectories.

Sivasubramanium V Bhavani1,2, Alexandra Spicer3, Pratik Sinha4, Albahi Malik5, Carlos Lopez-Espina6, Lee Schmalz6, Gregory L Watson6, Akhil Bhargava6, Shah Khan6, Dennys Urdiales6, Lincoln Updike6, Alon Dagan7, Hugo Davila8, Carmen Demarco8, Neil Evans9, Falgun Gosai10, Karthik Iyer11, Niko Kurtzman5, Ashok V Palagiri11, Matthew Sims8, Scott Smith8, Anwaruddin Syed10, Deesha Sarma7, Bobby Reddy6, Philip A Verhoef12, Matthew M Churpek3
1School of Medicine, Emory University, Atlanta, GA, USA. sivasubramanium.bhavani@emory.edu.
2Emory Critical Care Center, Atlanta, GA, USA. sivasubramanium.bhavani@emory.edu.
3Department of Medicine, University of Wisconsin, Madison, WI, USA.
4School of Medicine, Washington University, St. Louis, MO, USA.
5School of Medicine, Emory University, Atlanta, GA, USA.
6Prenosis, Inc., Chicago, IL, USA.
7Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
8Beaumont Health System, Royal Oak, MI, USA.
9Davis School of Medicine, University of California, Sacramento, CA, USA.
10OSF Saint Francis Medical Center, Peoria, IL, USA.
11Mercy Hospital, Jefferson, MO, USA.
12University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA.
PubMed PMC DOI PDF

Abstract

PURPOSE: Sepsis is a heterogeneous syndrome. Identification of sepsis subphenotypes with distinct immune profiles could lead to targeted therapies. This study investigates the immune profiles of patients with sepsis following distinct body temperature patterns (i.e., temperature trajectory subphenotypes). METHODS: Hospitalized patients from four hospitals between 2018 and 2022 with suspicion of i…

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