Peer-Reviewed Publication
NPJ Precis Oncol2024;8(1):221.October 3, 2024Journal Article
Proteomic basis for pancreatic acinar cell carcinoma and pancreatoblastoma as similar yet distinct entities.
Atsushi Tanaka1,2, Makiko Ogawa1,2, Yihua Zhou2,3, Ronald C Hendrickson4, Matthew M Miele4, Zhuoning Li4, David S Klimstra2,5, Julia Y Wang6, Michael H A Roehrl7,8
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
2Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
3ICU Department, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
4Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
5Paige.AI, New York, NY, USA.
6Curandis Biomedical, Chestnut Hill, MA, USA. julia@curandis.com.
7Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. michael_roehrl@bidmc.harvard.edu.
8Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. michael_roehrl@bidmc.harvard.edu.
Abstract
Acinar cell carcinoma (ACC) and pancreatoblastoma (PBL) are rare pancreatic malignancies with acinar differentiation. Proteogenomic profiling of ACC and PBL revealed distinct protein expression patterns compared to pancreatic ductal adenocarcinoma (PDAC) and benign pancreas. ACC and PBL exhibited similarities, with enrichment in proteins related to RNA processing, chromosome organization, and the…
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