Peer-Reviewed Publication
Eur Heart J Qual Care Clin Outcomes2025;11(4):434-444.June 23, 2025Journal Article
Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography.
Apostolos Tsiachristas1, Kenneth Chan2, Elizabeth Wahome2, Ben Kearns3, Parijat Patel2, Maria Lyasheva2, Nigar Syed4, Sam Fry4, Thomas Halborg2, Henry West2,5, Edward Nicol6,7, David Adlam8,9, Bhavik Modi8,9, Attila Kardos10, John P Greenwood11,12, Nikant Sabharwal2, Giovanni Luigi De Maria2, Shahzad Munir13, Elisa McAlindon13, Yogesh Sohan4, Pete Tomlins4, Muhammad Siddique4, Cheerag Shirodaria2,4, Ron Blankstein14, Milind Desai15, Stefan Neubauer2, Keith M Channon2, John Deanfield16, Ron Akehurst3, Charalambos Antoniades2,
1Nuffield Department of Primary Care Health Sciences & Department of Psychiatry, University of Oxford, Oxford, OX2 6GG, UK.
2Acute Multidisciplinary Imaging & Interventional Centre, British Heart Foundation (BHF) Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford NIHR Biomedical Research Centre, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.
3Lumanity, Sheffield, S1 2GQ, UK.
4Caristo Diagnostics, Oxford, OX2 0HP, UK.
5Sydney Medical School, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.
6Departments of Cardiology and Radiology, Royal Brompton Hospital, London, SW3 6NP, UK.
7School of Biomedical Engineering and Imaging Sciences, King's College, London, SE1 7EH, UK.
8Department of Cardiovascular Sciences, University of Leicester, Leicester, LE1 7RH, UK.
9NIHR Leicester Biomedical Research Centre, Leicester, LE3 9QP, UK.
10Department of Cardiology, Translational Cardiovascular Research Group, Milton Keynes University Hospital NHS Foundation Trust, Milton, MK6 5LD, UK.
11Leeds Teaching Hospitals, Leeds, LS1 3EX, UK.
12Baker Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
13Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK.
14Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
15Department of Cardiovascular Medicine, Cleveland Clinic Heart Vascular and Thoracic Institute, Cleveland, OH, 44195, USA.
16Institute of Cardiovascular Science, University College London, London, WC1E 6DD, UK.
Abstract
AIMS: Coronary computed tomography angiography (CCTA) is a first-line investigation for chest pain in patients with suspected obstructive coronary artery disease (CAD). However, many acute cardiac events occur in the absence of obstructive CAD. We assessed the lifetime cost-effectiveness of integrating a novel artificial intelligence-enhanced image analysis algorithm (AI-Risk) that stratifies the…
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