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Nat Commun2024;15(1):7547.August 30, 2024Journal Article

Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes.

Asolina Braun1, Louise C Rowntree2, Ziyi Huang1, Kirti Pandey1, Nikolas Thuesen3, Chen Li1, Jan Petersen1, Dene R Littler1, Shabana Raji2, Thi H O Nguyen2, Emma Jappe Lange3, Gry Persson3, Michael Schantz Klausen3, Jens Kringelum3, Shanzou Chung1, Nathan P Croft1, Pouya Faridi1, Rochelle Ayala1, Jamie Rossjohn1,4, Patricia T Illing1, Katherine E Scull1, Sri Ramarathinam1, Nicole A Mifsud1, Katherine Kedzierska2, Anders Bundgård Sørensen3, Anthony W Purcell5
1Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
2Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
3Evaxion Biotech, Hørsholm, Denmark.
4Institute of Infection and Immunity, Cardiff University, School of Medicine, Cardiff, UK.
5Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. anthony.purcell@monash.edu.
PubMed PMC DOI PDF

Abstract

Most COVID-19 vaccines elicit immunity against the SARS-CoV-2 Spike protein. However, Spike protein mutations in emerging strains and immune evasion by the SARS-CoV-2 virus demonstrates the need to develop more broadly targeting vaccines. To facilitate this, we use mass spectrometry to identify immunopeptides derived from seven relatively conserved structural and non-structural SARS-CoV-2 proteins…

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