Peer-Reviewed Publication
Mod Pathol2024;37(11):100585.November 1, 2024Clinical Trial, Phase II
SWI/SNF Complex-Deficient Undifferentiated Carcinoma of the Pancreas: Clinicopathologic and Genomic Analysis.
Aslihan Yavas1, Kerem Ozcan2, N Volkan Adsay3, Serdar Balci4, Zeynep C Tarcan5, Jaclyn F Hechtman6, Claudio Luchini7, Aldo Scarpa8, Rita T Lawlor9, Andrea Mafficini9, Michelle D Reid10, Yue Xue11, Zhaohai Yang12, Kester Haye12, Andrew M Bellizzi13, Alessandro Vanoli14, Jamal Benhamida15, Vinod Balachandran16, William Jarnagin16, Wungki Park17, Eileen M O'Reilly17, David S Klimstra18, Olca Basturk19
1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Pathology, Now with Institute of Pathology, Heinrich Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany.
2Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Now with Department of Pathology and Laboratory Medicine, Henry Ford Hospital, Detroit, Michigan.
3The Department of Pathology, Koç University Hospital and Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.
4Department of Pathology, Memorial Healthcare Group, Istanbul, Turkey.
5Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York.
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Now with Caris Life Sciences, Miami, Florida.
7Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy; ARC-Net Research Center, University and Hospital Trust of Verona, Verona, Italy.
8Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.
9Department of Engineering for Innovation Medicine (DIMI), University of Verona, Verona, Italy.
10Department of Pathology, School of Medicine, Emory University, Atlanta, Georgia.
11Department of Pathology, University Hospitals, Cleveland, Ohio.
12Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
13Department of Pathology, University of Iowa, Iowa City, Iowa; Department of Molecular Medicine, Unit of Anatomic Pathology, University of Pavia, Pavia, Italy.
14Unit of Anatomic Pathology, Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
15Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
16David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
17David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
18Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Now with Paige.AI, New York, New York.
19Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York. Electronic address: basturko@mskcc.org.
Abstract
Inactivating alterations in the SWItch/Sucrose NonFermentable (SWI/SNF) Chromatin Remodeling Complex subunits have been described in multiple tumor types. Recent studies focused on SMARC subunits of this complex to understand their relationship with tumor characteristics and therapeutic opportunities. To date, pancreatic cancer with these alterations has not been well studied, although isolated ca…
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