Simultaneous photoactivation of a fluoroquinolone antibiotic and nitric oxide with fluorescence reporting.

Tassia J Martins¹, Cristina Parisi¹, Juliana Guerra Pinto², Isabelle de Paula Ribeiro Brambilla², Barbara Melilli³, Danilo Aleo³, Juliana Ferreira-Strixino², Salvatore Sortino¹

¹PhotoChemLab, Department of Drug and Health Sciences, University of Catania, I-95125, Italy. ssortino@unict.it.

²Laboratory of Photobiology Applied to Health, Research and Development Institute, University of Vale do Paraíba, Urbanova I-2911, Brazil.

³MEDIVIS S.r.l., Tremestieri Etneo, 95030 Catania, Italy.

PubMed DOI

Abstract

The achievement of smart pharmaceuticals whose bioactivity can be spatiotemporally controlled by light stimuli is known as photopharmacology, an emerging area aimed at improving the therapeutic outcome and minimizing side effects. This is especially attractive for antibiotics, for which the inevitable development of multidrug resistance and the dwindling of new clinically approved drugs represent…

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