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Peer-Reviewed Publication
Discov Oncol2024;15(1):276.July 9, 2024Journal Article

Study of sex-biased differences in genomic profiles in East Asian hepatocellular carcinoma.

Chung-Yu Huang1, Kien-Thiam Tan1,2, Shiu-Feng Huang3, Yen-Jung Lu1, Yeh-Han Wang1,4,5, Shu-Jen Chen6, Ka-Po Tse7
1ACT Genomics Co., Ltd., Taipei, Taiwan.
2Anbogen Therapeutics, Inc., Taipei, Taiwan.
3Core Pathology Lab, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
4Department of Pathology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
5School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
6ACT Genomics Co., Ltd., Taipei, Taiwan. sjchen@actgenomics.com.
7ACT Genomics Co., Ltd., Taipei, Taiwan. bobotse@actgenomics.com.
PubMed PMC DOI PDF

Abstract

Hepatocellular carcinoma (HCC) is characterized by a notable sex disparity in incidence and tumor aggressiveness. Revealing differences in genetic landscapes between male and female HCCs may expand the understanding of sexual disparities mechanisms and assist the development of precision medicine. Although reports on the sex disparity of HCC are accumulated, studies focusing on sex-related biomark…

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