Natural Products Have Increased Rates of Clinical Trial Success throughout the Drug Development Process.

Daniel Domingo-Fernández¹, Yojana Gadiya¹, António José Preto¹, Christoph A Krettler¹, Sarah Mubeen¹, August Allen¹, David Healey¹, Viswa Colluru¹

¹Enveda Biosciences, 5700 Flatiron Parkway, Boulder, Colorado 80301, United States.

PubMed PMC DOI PDF

Abstract

Natural products (NPs) or their derivatives represent a large proportion of drugs that successfully progress through clinical trials to approval. This study explores the presence of NPs in both early- and late-stage drug discovery to determine their success rate, and the factors or features of natural products that contribute to such success. As a proxy for early drug development stages, we analyz…

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