Pan-cancer atlas of tumor-resident microbiome, immunity and prognosis.

Dashuang Sheng¹, Chuandi Jin², Kaile Yue², Min Yue², Yijia Liang², Xinxin Xue², Pingfu Li³, Guoping Zhao⁴, Lei Zhang⁵

¹Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.

²Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

³Shandong Huxley Medical Technology Co.,Ltd., Jinan, China.

⁴Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China; CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. Electronic address: gpzhao@sibs.ac.cn.

⁵Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China. Electronic address: zhanglei7@sdu.edu.cn.

PubMed DOI

Abstract

The existence of microbiome in human tumors has been determined widely, but evaluating the contribution of intratumoral bacteria and fungi to tumor immunity and prognosis from a pan-cancer perspective remains absent. We designed an improved microbial analysis pipeline to reduce interference from host sequences, complemented with integration analysis of intratumoral microbiota at species level with…

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