Health AI Central
Peer-Reviewed Publication
Front Oncol2024;141391464.January 1, 2024Journal Article

Immunotherapy and stereotactic body radiotherapy for older patients with non-metastatic renal cancer unfit for surgery or decline nephrectomy: practical proposal by the International Geriatric Radiotherapy Group.

Nam P Nguyen1, Monica-Emilia Chirila2,3, Brandi R Page4, Vincent Vinh-Hung5, Olena Gorobets6, Mohammad Mohammadianpanah7, Huan Giap8, Meritxell Arenas9, Marta Bonet10, Pedro Carlos Lara11, Lyndon Kim12, Fabien Dutheil13, David Lehrman14, Luis Zegarra Montes15, Ghassen Tlili16, Zineb Dahbi17, Gokoulakrichenane Loganadane18, Sergio Calleja Blanco19, Satya Bose1, Elena Natoli20,21, Eric Li22, Abba Mallum23, Alessio G Morganti20,21
1Department of Radiation Oncology, Howard University, Washington, DC, United States.
2Department of Clinical Development, MVision AI, Helsinki, Finland.
3Department of Radiation Oncology, Amethyst Radiotherapy Centre, Cluj-Napoca, Romania.
4Department of Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States.
5Department of Radiation Oncology, Centre Hospitalier Public du Contentin, Cherbourg-en-Contentin, France.
6Department of Oral Surgery, University Hospital of Martinique, Fort-de-France, France.
7Colorectal Research Center, Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.
8Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, United States.
9Department of Radiation Oncology, Sant Joan de Reus University Hospital, University of Rovira, I Virgili, Tarragona, Spain.
10Department of Radiation Oncology, Arnau de Vilanova University Hospital, Lleida, Spain.
11Department of Radiation Oncology, Fernando Pessoria Canarias Las Palmas University, Las Palmas, Spain.
12Division of Neuro-Oncology, Mount Sinai Hospital, New York, NY, United States.
13Department of Radiation Oncology, Clinique Sainte Clotilde, Saint-Denis, Reunion Island, France.
14Department of Radiation Oncology, International Geriatric Radiotherapy Group, Washington, DC, United States.
15Department of Urology, University of Peruana, Lima, Peru.
16Department of Urology, Sahloul University Hospital, Sousse, Tunisia.
17Department of Radiation Oncology, Mohammed VI University of Health Sciences, Casablanca, Morocco.
18Department of Radiation Oncology, Institut Curie, Paris, France.
19Department of Oral Maxillofacial Surgery, Howard University, Washington, DC, United States.
20Department of Radiation Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy.
21Radiation Oncology, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studorium, Bologna University, Bologna, Italy.
22Department of Pathology, Howard University, Washington, DC, United States.
23Department of Radiation Oncology, University of KwaZulu Natal, Durban, South Africa.
PubMed PMC DOI PDF

Abstract

The standard of care for non-metastatic renal cancer is surgical resection followed by adjuvant therapy for those at high risk for recurrences. However, for older patients, surgery may not be an option due to the high risk of complications which may result in death. In the past renal cancer was considered to be radio-resistant, and required a higher dose of radiation leading to excessive complicat…

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