Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order?

Felix Eckstein¹, Anna Wisser², Susanne Maschek², Wolfgang Wirth², Christoph Ladel³, Asger Reinstrup Bihlet⁴, Chris Knight⁵, Kenneth Somberg⁵, Luping Zhao⁵

¹Research Program for Musculoskeletal Imaging, Center for Anatomy & Cell Biology, Paracelsus Medical University (PMU), Salzburg, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University (PMU), Salzburg, Austria; Chondrometrics GmbH, Freilassing, Germany. Electronic address: felix.eckstein@pmu.ac.at.

²Research Program for Musculoskeletal Imaging, Center for Anatomy & Cell Biology, Paracelsus Medical University (PMU), Salzburg, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University (PMU), Salzburg, Austria; Chondrometrics GmbH, Freilassing, Germany.

³CHL4special consulting, Darmstadt, Germany.

⁴NBCD A/S, Copenhagen, Denmark.

⁵Formation Bio, New York, NY, United States.

PubMed DOI

Abstract

OBJECTIVE: We here explore whether observed treatment effects of a putative disease-modifying osteoarthritis drug (DMOAD) are greater when cartilage morphometry is performed with rather than without knowledge of magnetic resonance imaging (MRI) acquisition order (unblinded/blinded to time point). METHODS: In the FORWARD (FGF-18 Osteoarthritis Randomized Controlled Trial with Administration of Rep…

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