Health AI Central
Peer-Reviewed Publication
Am J Prev Cardiol2024;18100672.June 1, 2024Journal Article

Health economic analysis of polygenic risk score use in primary prevention of coronary artery disease - A system dynamics model.

Stephen T Vernon1,2,3, Stuart Brentnall4, Danielle J Currie4, Cindy Peng4, Michael P Gray1,3, Giordano Botta5, Deo Mujwara5, Stephen J Nicholls6, Stuart M Grieve7,8, Julie Redfern9, Clara Chow10, Jean-Frederic Levesque11,12, Peter J Meikle13,14, Garry Jennings15, Zanfina Ademi16,17, Andrew Wilson18, Gemma A Figtree1,2,3
1Cardiovascular Discovery Group, Kolling Institute of Medical Research, University of Sydney, Australia.
2Department of Cardiology, Royal North Shore Hospital, Australia.
3Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Australia.
4Decision Analytics, The SAX Institute, Sydney, Australia.
5Allelica Inc, New York, United States.
6Monash Cardiovascular Research Centre, Monash University, Melbourne, Victoria, Australia.
7Imaging and Phenotyping Laboratory, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
8Sydney Medical School and School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
9School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
10Westmead Applied Research Centre (C.K.C.), University of Sydney, Australia.
11NSW Health, Sydney, NSW, Australia.
12Centre for Primary Health Care and Equity, University of New South Wales, Sydney, NSW, Australia.
13Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
14Monash University, Melbourne, VIC, 3800, Australia.
15University of Sydney, Sydney, NSW, Australia.
16Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia.
17School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
18Menzies Centre for Health Policy and Economics, Faculty of Medicine and Health, School of Public Health, The University of Sydney, Sydney, Australia.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Primary prevention programs utilising traditional risk scores fail to identify all individuals who suffer acute cardiovascular events. We aimed to model the impact and cost effectiveness of incorporating a Polygenic risk scores (PRS) into the cardiovascular disease CVD primary prevention program in Australia, using a whole-of-system model. METHODS: System dynamics models, encompassing…

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