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Nat Neurosci2024;27(6):1064-1074.June 1, 2024Journal Article

Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.

Kynon J M Benjamin1,2,3, Qiang Chen4, Nicholas J Eagles4, Louise A Huuki-Myers4, Leonardo Collado-Torres4,5, Joshua M Stolz4, Geo Pertea4, Joo Heon Shin4, Apuã C M Paquola4,6, Thomas M Hyde4,6,7, Joel E Kleinman4,7, Andrew E Jaffe7,8,9, Shizhong Han10,11,12, Daniel R Weinberger13,14,15,16,17
1Lieber Institute for Brain Development, Baltimore, MD, USA. KynonJade.Benjamin@libd.org.
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. KynonJade.Benjamin@libd.org.
3Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. KynonJade.Benjamin@libd.org.
4Lieber Institute for Brain Development, Baltimore, MD, USA.
5Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.
6Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
7Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
8Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
9Neumora Therapeutics, Watertown, MA, USA.
10Lieber Institute for Brain Development, Baltimore, MD, USA. Shizhong.Han@libd.org.
11Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Shizhong.Han@libd.org.
12Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Shizhong.Han@libd.org.
13Lieber Institute for Brain Development, Baltimore, MD, USA. drweinberger@libd.org.
14Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. drweinberger@libd.org.
15Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. drweinberger@libd.org.
16Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. drweinberger@libd.org.
17Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. drweinberger@libd.org.
PubMed PMC DOI PDF

Abstract

Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to European ancestry samples or adjusted to identify ancestry-independent associations. Here, we instead examined the impact of genetic ancestry on gene expression and DNA methylation in the postmortem brain tissue of admixed Black American neurotypical indiv…

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