High-Throughput Compound Quality Assessment with High-Mass-Resolution Acoustic Ejection Mass Spectrometry: An Automatic Data Processing Toolkit.

Alandra Quinn¹, Gordana Ivosev², Jefferson Chin^1,3, Robert Mongillo¹, Cristiano Veiga^2,4, Thomas R Covey², Brendon Kapinos¹, Bhagyashree Khunte¹, Hui Zhang^1,5, Matthew D Troutman¹, Chang Liu²

¹Pfizer Global Research and Development, Groton, Connecticut 06340, United States.

²SCIEX, 71 Four Valley Drive, Concord, Ontario L4K 4V8, Canada.

³AssayQuant Technologies, Marlborough, Massachusetts 01752, United States.

⁴Red Hat, Toronto, Ontario M5C 3G8, Canada.

⁵Iambic Therapeutics, San Diego, California 92121, United States.

PubMed DOI

Abstract

Pharmacological screening heavily relies on the reliability of compound libraries. To ensure the accuracy of screening results, fast and reliable quality control (QC) of these libraries is essential. While liquid chromatography (LC) with ultraviolet (UV) or mass spectrometry (MS) detection has been employed for molecule QC on small sample sets, the analytical throughput becomes a bottleneck when d…

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