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Peer-Reviewed Publication
Ann Hematol2024;103(8):2917-2930.August 1, 2024Journal Article

Analysis of mutation profiles in extranodal NK/T-cell lymphoma: clinical and prognostic correlations.

Yu-Cheng Chang1,2,3,4, Hui-Jen Tsai5,6, To-Yu Huang4, Nai-Wen Su2,3,4, Ying-Wen Su2,3,4,7, Yi-Fang Chang2,3,4, Caleb Gon-Shen Chen2,3,4,7,8, Johnson Lin2, Ming-Chih Chang2,3, Shu-Jen Chen9, Hua-Chien Chen9, Ken-Hong Lim10,11,12, Kung-Chao Chang13, Sung-Hsin Kuo14,15
1Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan.
2Division of Hematology and Oncology, Department of Internal Medicine, MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, New Taipei City, 10449, Taiwan.
3Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
4Laboratory of Good Clinical Research Center, Department of Medical Research, MacKay Memorial Hospital, Tamsui District, New Taipei City, Taiwan.
5National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
6Department of Oncology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
7Department of Nursing, Nursing, and Management, MacKay Junior College of Medicine, New Taipei City, Taiwan.
8Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
9ACT Genomics Co., Ltd, Taipei, Taiwan.
10Division of Hematology and Oncology, Department of Internal Medicine, MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, New Taipei City, 10449, Taiwan. limkenhong@gmail.com.
11Department of Medicine, MacKay Medical College, New Taipei City, Taiwan. limkenhong@gmail.com.
12Laboratory of Good Clinical Research Center, Department of Medical Research, MacKay Memorial Hospital, Tamsui District, New Taipei City, Taiwan. limkenhong@gmail.com.
13Department of Pathology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. changkc@mail.ncku.edu.tw.
14Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan. shkuo101@ntu.edu.tw.
15Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan. shkuo101@ntu.edu.tw.
PubMed DOI

Abstract

The molecular pathogenesis of extranodal NK/T-cell lymphoma (NKTCL) remains obscured despite the next-generation sequencing (NGS) studies explored on ever larger cohorts in the last decade. We addressed the highly variable mutation frequencies reported among previous studies with comprehensive amplicon coverage and enhanced sequencing depth to achieve higher genomic resolution for novel genetic di…

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