Health AI Central
Peer-Reviewed Publication
Front Toxicol2024;61377542.January 1, 2024Journal Article

Digitalization of toxicology: improving preclinical to clinical translation.

Brian R Berridge1, Szczepan W Baran2, Vivek Kumar3, Natalie Bratcher-Petersen4, Michael Ellis3, Chang-Ning Liu5, Timothy L Robertson3,4
1B2 Pathology Solutions LLC, Cary, NC, United States.
2VeriSIM Life, San Francisco, CA, United States.
3The Jackson Laboratory, Bar Harbor, ME, United States.
4TLR Ventures, Redwood City, CA, United States.
5Drug Safety Research and Development, Pfizer, Groton, CT, United States.
PubMed PMC DOI PDF

Abstract

Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day. Safety liabilities are a significant contributor to development attrition where the costliest liabilities to both drug developers and patients emerge in late development or post-marketing. Animal studies are an im…

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