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Peer-Reviewed Publication
Biomed Pharmacother2024;174116442.May 1, 2024Journal Article

Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson's disease.

Jae-Bong Kim1, Soo-Jeong Kim2, Minyoung So3, Dong-Kyu Kim2, Hye Rin Noh1, Beom Jin Kim1, Yu Ree Choi2, Doyoon Kim4, Heejung Koo3, Taeyong Kim3, Hyun Goo Woo4, Sang Myun Park5
1Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea; Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.
2Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea.
3Standigm Inc., Seoul, Korea.
4Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea; Department of Physiology, Ajou University School of Medicine, Suwon, Korea.
5Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea; Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea. Electronic address: sangmyun@ajou.ac.kr.
PubMed DOI

Abstract

Parkinson's disease (PD) is a complex neurodegenerative disorder with an unclear etiology. Despite significant research efforts, developing disease-modifying treatments for PD remains a major unmet medical need. Notably, drug repositioning is becoming an increasingly attractive direction in drug discovery, and computational approaches offer a relatively quick and resource-saving method for identif…

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