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Peer-Reviewed Publication
JCI Insight2024;9(8)March 21, 2024Journal Article

Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers.

Hannah F Schiff1,2, Naomi F Walker3, Cesar Ugarte-Gil4,5, Marc Tebruegge6,7,8, Antigoni Manousopoulou9, Spiros D Garbis1,9, Salah Mansour1,2, Pak Ho Michael Wong10, Gabrielle Rockett10, Paolo Piazza10, Mahesan Niranjan2,11, Andres F Vallejo1, Christopher H Woelk12, Robert J Wilkinson13,14,15,16, Liku B Tezera1,2, Diana Garay-Baquero1,2, Paul Elkington1,2
1NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
2Institute for Life Sciences, Southampton, United Kingdom.
3Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
4Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
5Department of Epidemiology, School of Public and Population Health, University of Texas Medical Branch, Galveston, Texas, USA.
6Department of Infection, Immunity & Inflammation, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
7Department of Paediatrics, Klinik Ottakring, Wiener Gesundheitsverbund, Vienna, Austria.
8Department of Paediatrics, The University of Melbourne, Parkville, Australia.
9Proteas Bioanalytics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA.
10Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
11Electronics and Computer Sciences, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, United Kingdom.
12Verge Genomics, South San Francisco, California, USA.
13Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, and.
14Department of Medicine, University of Cape Town, Observatory, Republic of South Africa.
15Department of Infectious Diseases, Imperial College London, London, United Kingdom.
16The Francis Crick Institute, London, United Kingdom.
PubMed PMC DOI PDF

Abstract

BACKGROUNDNovel biomarkers to identify infectious patients transmitting Mycobacterium tuberculosis are urgently needed to control the global tuberculosis (TB) pandemic. We hypothesized that proteins released into the plasma in active pulmonary TB are clinically useful biomarkers to distinguish TB cases from healthy individuals and patients with other respiratory infections.METHODSWe applied a high…

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