Peer-Reviewed Publication
BMJ Open2024;14(3):e077534.March 4, 2024Clinical Trial Protocol
DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia (DECONNECT): research protocol for a cross-sectional pilot study.
Yentl Brandt1,2, Robert-Jan Alers3,4, Lisanne P W Canjels3,5, Laura M Jorissen3,4, Gwyneth Jansen3,4, Emma B N J Janssen2,3, Sander van Kuijk6, Tamara Michelle Went1, Dennis Koehn7, Suzanne C Gerretsen1, Jacobus Jansen1,8,9, Walter Backes1,2,9, Petra P M Hurks10, Vincent van de Ven11, M Eline Kooi1,2, Marc E A Spaanderman3,4,5, Chahinda Ghossein-Doha12,13,14
1Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
2School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, The Netherlands.
3Department of Obstetrics and Gynaecology, Maastricht University Medical Center+, Maastricht, The Netherlands.
4School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, The Netherlands.
5Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands.
6Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, Maastricht, The Netherlands.
7Pie Medical Imaging BV, Maastricht, The Netherlands.
8Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
9School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands.
10Department of Neuropsychology and Psychofarmacology, Maastricht University, Maastricht, The Netherlands.
11Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands.
12School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, The Netherlands c.ghossein-doha@erasmusmc.nl.
13Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
14Department of Cardiology, Maastricht University Medical Center+, Maastricht, The Netherlands.
Abstract
INTRODUCTION: Pre-eclampsia is a hypertensive disorder affecting up to 8% of pregnancies. After pre-eclampsia, women are at increased risk of cognitive problems, and cerebrovascular and cardiovascular disorders. These sequelae could result from microvascular dysfunction persisting after pre-eclampsia. This study will explore differences in cerebral and myocardial microvascular function between wom…
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