Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma.

Lars H Nordenmark¹, Åsa Hellqvist², Claire Emson³, Sarah Diver⁴, Celeste Porsbjerg⁵, Janet M Griffiths³, John D Newell^6,7, Samuel Peterson⁷, Beata Pawlikowska⁸, Jane R Parnes⁹, Ayman Megally¹⁰, Gene Colice¹⁰, Christopher E Brightling⁴

¹Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Oslo.

²Biometrics, Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

³Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD.

⁴National Institute for Health and Care Research, Leicester Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.

⁵Department of Respiratory Medicine, Bispebjerg University Hospital, University of Copenhagen, Copenhagen.

⁶Department of Radiology and Biomedical Engineering, University of Iowa, Iowa City.

⁷VIDA Diagnostics, Coralville, IA.

⁸Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Warsaw, Poland.

⁹Early Development, Amgen, Thousand Oaks, CA.

¹⁰Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD.

PubMed DOI

Abstract

BACKGROUND: Mucus plugs in asthmatic airways are associated with airway obstruction and the activity of inflammatory cytokines, specifically interleukin (IL)-5 and IL-13, and they may provide an opportunity for targeted therapy. This analysis of the CASCADE (Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma) placebo-controlled trial used computed tomography (C…

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