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Int J Cardiol2024;399131668.March 15, 2024Journal Article

Influence of intracoronary hemodynamic forces on atherosclerotic plaque phenotypes.

Alessandro Candreva1, Diego Gallo2, Daniel Munhoz3, Maurizio Lodi Rizzini2, Takuya Mizukami4, Ruiko Seki5, Koshiro Sakai5, Jeroen Sonck6, Valentina Mazzi2, Brian Ko7, Bjarne Linde Nørgaard8, Jesper Møller Jensen8, Michael Maeng8, Hiromasa Otake9, Bon-Kwon Koo10, Toshiro Shinke11, Jean-Paul Aben12, Daniele Andreini13, Emanuele Gallinoro14, Barbara E Stähli15, Christian Templin16, Claudio Chiastra2, Bernard De Bruyne17, Umberto Morbiducci2, Carlos Collet18
1Department of Cardiology, Zurich University Hospital, Zurich, Switzerland; Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; PoliTo(BIO) Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
2PoliTo(BIO) Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
3Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; Department of internal medicine, University of Campinas (Unicamp), Campinas, Brazil.
4Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Cardiology, Showa University School of Medicine, Tokyo, Japan.
5Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
6Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
7Monash Cardiovascular Research Centre, Monash University and Monash Heart, Monash Health, Clayton, Victoria, Australia.
8Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
9Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Cardiology, Aichi Medical University, Aichi, Japan.
10Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea.
11Department of Cardiology, Showa University School of Medicine, Tokyo, Japan.
12Pie Medical Imaging BV, Maastricht, the Netherlands.
13Department of Cardiology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy and Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
14Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Cardiology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy and Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
15Department of Cardiology, Zurich University Hospital, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.
16Department of Cardiology, Zurich University Hospital, Zurich, Switzerland.
17Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
18Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium. Electronic address: carloscollet@gmail.com.
PubMed DOI

Abstract

BACKGROUND AND AIMS: Coronary hemodynamics impact coronary plaque progression and destabilization. The aim of the present study was to establish the association between focal vs. diffuse intracoronary pressure gradients and wall shear stress (WSS) patterns with atherosclerotic plaque composition. METHODS: Prospective, international, single-arm study of patients with chronic coronary syndromes and…

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