Peer-Reviewed Publication
Chest2024;165(4):775-784.April 1, 2024Journal Article
Use of Quantitative CT Imaging to Identify Bronchial Thermoplasty Responders.
Maanasi Samant1, James G Krings1, Daphne Lew2, Charles W Goss2, Tammy Koch1, Mary Clare McGregor1, Jonathan Boomer3, Chase S Hall3, Ken B Schechtman2, Ajay Sheshadri4, Samuel Peterson5, Serpil Erzurum6, Zachary DePew7, Lee E Morrow7, D Kyle Hogarth8, Richard Tejedor9, Jennifer Trevor10, Michael E Wechsler11, Afshin Sam12, Xiaosong Shi3, Jiwoong Choi3, Mario Castro13
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, MO.
2Division of Biostatistics, Washington University in Saint Louis School of Medicine, Saint Louis, MO.
3Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Kansas School of Medicine, Kansas City, KS.
4Division of Pulmonary Critical Care Medicine, Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
5VIDA Diagnostics, Coralville, IA.
6Lerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH.
7Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Creighton University Medical Center, Omaha, NE.
8Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL.
9Division of Pulmonary and Critical Care, Department of Medicine, LSU Health Sciences Center, New Orleans, LA.
10Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
11Department of Medicine, National Jewish Health, Denver, CO.
12Division of Pulmonary and Critical Care, Department of Medicine, University of Arizona, Tuscon, AZ.
13Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Kansas School of Medicine, Kansas City, KS. Electronic address: mcastro2@kumc.edu.
Abstract
BACKGROUND: Bronchial thermoplasty (BT) is a treatment for patients with poorly controlled, severe asthma. However, predictors of treatment response to BT are defined poorly.
RESEARCH QUESTION: Do baseline radiographic and clinical characteristics exist that predict response to BT?
STUDY DESIGN AND METHODS: We conducted a longitudinal prospective cohort study of participants with severe asthma r…
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