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Peer-Reviewed Publication
J Cardiovasc Magn Reson2023;25(1):77.December 14, 2023Journal Article

Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge.

Peder E Z Larson1,2, Shuyu Tang3,4,5, Xiaoxi Liu3, Avantika Sinha3, Nicholas Dwork3,6, Sanjay Sivalokanathan7, Jing Liu3, Robert Bok3, Karen G Ordovas3,8, James Slater3, Jeremy W Gordon3, M Roselle Abraham9
1Department of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA. peder.larson@ucsf.edu.
2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, CA, USA. peder.larson@ucsf.edu.
3Department of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
4UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, CA, USA.
5Vista.ai, Palo Alto, CA, USA.
6Departments of Bioinformatics and Radiology, University of Colorado School of Medicine, Denver, CO, USA.
7Division of Internal Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
8Department of Radiology, University of Washington, Seattle, WA, USA.
9Cardiology Division, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) 13C-pyruvate MRI is a promising new tool for non-invasive quantification of myocardial glycolytic and Krebs cycle flux. However, human studies of HP 13C-MRI have yet to demonstrate regional quantification…

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