Integrated antibody and cellular immunity monitoring are required for assessment of the long term protection that will be essential for effective next generation vaccine development.

Eustache Paramithiotis¹, Christophe Varaklis², Stephane Pillet³, Shahin Shafiani⁴, Mary Pat Lancelotta⁴, Steve Steinhubl^5,6, Scott Sugden⁷, Matt Clutter¹, Damien Montamat-Sicotte¹, Todd Chermak², Stephanie Y Crawford⁸, Bruce L Lambert⁹, John Mattison¹⁰, Robert L Murphy¹¹

¹Research and Development, CellCarta, Montreal, QC, Canada.

²Regulatory and Government Affairs, CellCarta, Montreal, QC, Canada.

³McGill University Health Center, Montreal, QC, Canada.

⁴Adaptive Biotechnologies, Seattle, WA, United States.

⁵Purdue University, West Lafayette, IN, United States.

⁶PhysIQ, Chicago, IL, United States.

⁷Medical and Scientific Affairs, Infectious Diseases, Cepheid, Sunnyvale, CA, United States.

⁸Department of Pharmacy Systems, Outcomes and Policy, University of Illinois Chicago, Chicago, IL, United States.

⁹Department of Communication Studies, Institute for Global Health, Northwestern University, Evanston, IL, United States.

¹⁰Health Technology Advisory Board, Arsenal Capital, New York, NY, United States.

¹¹Robert J. Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.

PubMed PMC DOI PDF

Abstract

The COVID pandemic exposed the critical role T cells play in initial immunity, the establishment and maintenance of long term protection, and of durable responsiveness against novel viral variants. A growing body of evidence indicates that adding measures of cellular immunity will fill an important knowledge gap in vaccine clinical trials, likely leading to improvements in the effectiveness of the…

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