Peer-Reviewed Publication
J Alzheimers Dis2024;97(2):829-839.January 1, 2024Journal Article
Exercise-Related Physical Activity Relates to Brain Volumes in 10,125 Individuals.
Cyrus A Raji1,2, Somayeh Meysami3,4, Sam Hashemi5,6, Saurabh Garg2,6, Nasrin Akbari5,6, Gouda Ahmed5,6, Yosef Gavriel Chodakiewitz5, Thanh Duc Nguyen5,6, Kellyann Niotis7,8, David A Merrill3,4,9, Rajpaul Attariwala5,6,10
1Washington University School of Medicine in St Louis, Mallinckrodt Institute of Radiology, St. Louis, MO, USA.
2Department of Neurology, Washington University in St. Louis, MO, USA.
3Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.
4Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
5Prenuvo, VA, Canada.
6Voxelwise Imaging Technology, VA, Canada.
7Early Medical, Austin, TX, USA.
8The Institute for Neurodegenerative Diseases-Florida, Boca Raton, FL, USA.
9Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
10AIM Medical Imaging, VA, Canada.
Abstract
BACKGROUND: The potential neuroprotective effects of regular physical activity on brain structure are unclear, despite links between activity and reduced dementia risk.
OBJECTIVE: To investigate the relationships between regular moderate to vigorous physical activity and quantified brain volumes on magnetic resonance neuroimaging.
METHODS: A total of 10,125 healthy participants underwent whole-b…
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