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Peer-Reviewed Publication
J Am Heart Assoc2023;12(22):e030934.November 21, 2023Journal Article

Validation of an Integrated Genetic-Epigenetic Test for the Assessment of Coronary Heart Disease.

Robert Philibert1,2,3, Timur K Dogan1, Stacey Knight4,5, Ferhaan Ahmad6, Stanley Lau7, George Miles8, Kirk U Knowlton4, Meeshanthini V Dogan1,3
1Cardio Diagnostics Inc Chicago IL USA.
2Department of Psychiatry University of Iowa Iowa City IA USA.
3Department of Biomedical Engineering University of Iowa Iowa City IA USA.
4Intermountain Heart Institute, Intermountain Healthcare Salt Lake City UT USA.
5Department of Internal Medicine University of Utah Salt Lake City UT USA.
6Division of Cardiovascular Medicine, Department of Internal Medicine University of Iowa Iowa City IA USA.
7Southern California Heart Centers San Gabriel CA USA.
8Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Coronary heart disease (CHD) is the leading cause of death in the world. Unfortunately, many of the key diagnostic tools for CHD are insensitive, invasive, and costly; require significant specialized infrastructure investments; and do not provide information to guide postdiagnosis therapy. In prior work using data from the Framingham Heart Study, we provided in silico evidence that int…

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