Exploring the known chemical space of the plant kingdom: insights into taxonomic patterns, knowledge gaps, and bioactive regions.

Daniel Domingo-Fernández¹, Yojana Gadiya², Sarah Mubeen², David Healey², Bryan H Norman², Viswa Colluru²

¹Enveda Biosciences, Boulder, CO, USA. daniel.domingo-fernandez@envedabio.com.

²Enveda Biosciences, Boulder, CO, USA.

Abstract

Plants are one of the primary sources of natural products for drug development. However, despite centuries of research, only a limited region of the phytochemical space has been studied. To understand the scope of what is explored versus unexplored in the phytochemical space, we begin by reconstructing the known chemical space of the plant kingdom, mapping the distribution of secondary metabolites…

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