Peer-Reviewed Publication
medRxiv2023October 19, 2023Preprint
Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate MRI evaluated in an oral glucose challenge.
Peder E Z Larson1,2, Shuyu Tang1,2,3, Xiaoxi Liu1, Avantika Sinha1, Nicholas Dwork1,4, Sanjay Sivalokanathan5, Jing Liu1, Robert Bok1, Karen G Ordovas1, James Slater1, Jeremy W Gordon1, M Roselle Abraham6
1Department of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.
2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.
3Vista.ai, Palo Alto, CA, USA.
4Departments of Bioinformatics and Radiology, University of Colorado School of Medicine, Denver, CO, USA.
5Department of Medicine - Division of Internal Medicine, University of Pennsylvania, Philadelphia, PA, USA.
6Department of Medicine - Cardiology Division, University of California - San Francisco, San Francisco, California, USA.
Abstract
BACKGROUND: The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) 13C-pyruvate MRI is a promising new tool for non-invasive quantification of myocardial glycolytic and Krebs cycle flux. However, human studies of HP 13C-MRI have yet to demonstrate regional quantification…
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