Peer-Reviewed Publication
Allergy2024;79(1):128-141.January 1, 2024Journal Article
Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin.
Arturo O Rinaldi1, Manru Li1, Elena Barletta1, Paolo D'Avino1, Duygu Yazici1, Yagiz Pat1, Siobhan Ward1,2, Daniel Burla1, Ge Tan1, Nima Askary3, Rasmus Larsson3, Jeremy Bost3, Huseyn Babayev1, Raja Dhir4, Nicolas Gaudenzio5,6, Mubeccel Akdis1, Kari Nadeau7, Cezmi A Akdis1,2, Yasutaka Mitamura1
1Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.
2Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
3SciBase AB, Sundbyberg, Sweden.
4SEED, Inc, Co, Los Angeles, California, USA.
5Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291, CNRS UMR5051, University Toulouse III, Toulouse, France.
6Genoskin SAS, Toulouse, France.
7Department of Environmental Studies, Harvard T.H. Chan School of Public Health, Cambridge, Massachusetts, USA.
Abstract
BACKGROUND: Epithelial barrier impairment is associated with many skin and mucosal inflammatory disorders. Laundry detergents have been demonstrated to affect epithelial barrier function in vitro using air-liquid interface cultures of human epithelial cells.
METHODS: Back skin of C57BL/6 mice was treated with two household laundry detergents at several dilutions. Barrier function was assessed by…
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