Electrical impedance spectroscopy detects skin barrier dysfunction in childhood atopic dermatitis.

Mari Sasaki¹, Mathilda Sundberg², Remo Frei^3,4,5, Ruth Ferstl^3,6,7, Kristina N Heye⁷, Erik P Willems⁸, Cezmi A Akdis^3,6, Roger Lauener^3,7, , Caroline Roduit^1,3,4,7

¹University Children's Hospital Zürich, Zürich, Switzerland.

²SciBase AB, Sundbyberg, Sweden.

³Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.

⁴Division of Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, University of Bern, Bern, Switzerland.

⁵Department of Biomedical Research, University of Bern, Bern, Switzerland.

⁶Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland.

⁷Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland.

⁸Clinical Trials Unit, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

PubMed DOI

Abstract

BACKGROUND: Skin barrier dysfunction is associated with the development of atopic dermatitis (AD), however methods to assess skin barrier function are limited. We investigated the use of electrical impedance spectroscopy (EIS) to detect skin barrier dysfunction in children with AD of the CARE (Childhood AlleRgy, nutrition, and Environment) cohort. METHODS: EIS measurements taken at multiple time…

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