Peer-Reviewed Publication
Ann Biomed Eng2024;52(2):226-238.February 1, 2024Journal Article
Blood Flow Energy Identifies Coronary Lesions Culprit of Future Myocardial Infarction.
Maurizio Lodi Rizzini1, Alessandro Candreva1,2, Valentina Mazzi1, Mattia Pagnoni3, Claudio Chiastra1, Jean-Paul Aben4, Stephane Fournier3,5, Stephane Cook6, Olivier Muller3, Bernard De Bruyne7, Takuya Mizukami7, Carlos Collet7, Diego Gallo1, Umberto Morbiducci8
1PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy.
2Department of Cardiology, Zurich University Hospital, Zurich, Switzerland.
3Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
4Pie Medical Imaging BV, Maastricht, The Netherlands.
5Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
6Department of Cardiology, HFR Fribourg, Fribourg, Switzerland.
7Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
8PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy. umberto.morbiducci@polito.it.
Abstract
The present study establishes a link between blood flow energy transformations in coronary atherosclerotic lesions and clinical outcomes. The predictive capacity for future myocardial infarction (MI) was compared with that of established quantitative coronary angiography (QCA)-derived predictors. Angiography-based computational fluid dynamics (CFD) simulations were performed on 80 human coronary l…
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