Peer-Reviewed Publication
Aging Dis2024;15(4):1831-1842.August 1, 2024Journal Article
Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals.
Cyrus A Raji1, Somayeh Meysami2,3, Sam Hashemi4,5, Saurabh Garg4,5, Nasrin Akbari4,5, Ahmed Gouda4,5, Yosef Gavriel Chodakiewitz4, Thanh Duc Nguyen4,5, Kellyann Niotis6,7, David A Merrill2,8,9, Rajpaul Attariwala10,4,5
1Mallinckrodt Institute of Radiology, Neuroradiology Division, Washington University in St. Louis, MO, USA.
2Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.
3Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.
4Prenuvo, Vancouver, Canada.
5Voxelwise Imaging Technology, Vancouver, Canada.
6Early Medical, Boca Raton, FL, USA.
7Institute of Neurodegenerative Diseases-Parkinson's & Alzheimer's Research Education Foundation, Boca Raton, FL, USA.
8Providence Saint John's Health Center, Santa Monica, CA, USA.
9Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
10AIM Medical Imaging, Vancouver, Canada.
Abstract
Abdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSurfer segmented 96 brain regions. Separate models segmented visceral and subcutaneous abdominal fat. Regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling for age and…
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