Nitrosylation of β2-Tubulin Promotes Microtubule Disassembly and Differentiated Cardiomyocyte Beating in Ischemic Mice.

Da Hyeon Choi¹, Seong Ki Kang^2,3, Kyeong Eun Lee¹, Jongsun Jung⁴, Eun Ju Kim⁵, Won-Ho Kim⁶, Young-Guen Kwon⁷, Kwang Pyo Kim⁵, Inho Jo^8,9, Yoon Shin Park¹⁰, Sang Ick Park¹¹

¹Department of Biological Sciences and Biotechnology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju, Republic of Korea.

²Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health (KNIH), Cheongju, Republic of Korea.

³Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Republic of Korea.

⁴AI Drug Platform Center, Syntekabio, Daejeon, Republic of Korea.

⁵Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea.

⁶Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Republic of Korea.

⁷Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

⁸Department of Molecular Medicine, College of Ewha Womans University, Seoul, Republic of Korea.

⁹Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Republic of Korea.

¹⁰Department of Biological Sciences and Biotechnology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju, Republic of Korea. pys@cbnu.ac.kr.

¹¹Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health (KNIH), Cheongju, Republic of Korea. parksi61@hotmail.com.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Beating cardiomyocyte regeneration therapies have revealed as alternative therapeutics for heart transplantation. Nonetheless, the importance of nitric oxide (NO) in cardiomyocyte regeneration has been widely suggested, little has been reported concerning endogenous NO during cardiomyocyte differentiation. METHODS: Here, we used P19CL6 cells and a Myocardiac infarction (MI) model to c…

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