Non-Invasive Transcutaneous Afferent Patterned Stimulation Therapy Offers Action Tremor Relief in Parkinson's Disease.

Salima Brillman¹, Pravin Khemani², Stuart H Isaacson³, Rajesh Pahwa⁴, Ruta Deshpande⁵, Vivien Zraick⁵, Apoorva Rajagopal⁵, Dhira Khosla⁵, Kathryn H Rosenbluth⁵

¹Parkinson's Disease and Movement Disorders Center of Silicon Valley, Palo Alto, CA, US.

²Swedish Neuroscience Institute, Seattle, WA, US.

³Parkinson's Disease and Movement Disorders of Boca Raton, Boca Raton, FL, US.

⁴University of Kansas Medical Center, Kansas City, KS, US.

⁵Cala Health, Inc., San Mateo, CA, US.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Many patients with Parkinson's disease (PD) experience action tremor (including postural and kinetic tremors) that impair activities of daily living. Transcutaneous afferent patterned stimulation (TAPS) is a non-invasive neuromodulation therapy that modulates tremorgenic activity at the ventral intermediate nucleus (VIM). Most TAPS evidence evaluated relief of action tremor associated…

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