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Peer-Reviewed Publication
Mol Microbiol2023;120(2):298-306.August 1, 2023Journal Article

Escherichia coli DNA repair helicase Lhr is also a uracil-DNA glycosylase.

Ryan J Buckley1, Anna Lou-Hing1, Karl M Hanson2, Nadia R Ahmed2, Christopher D O Cooper2,3, Edward L Bolt1
1School of Life Sciences, University of Nottingham, Nottingham, UK.
2School of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
3CHARM Therapeutics Ltd, B900 Babraham Research Campus, Cambridge, UK.
PubMed PMC DOI PDF

Abstract

DNA glycosylases protect genetic fidelity during DNA replication by removing potentially mutagenic chemically damaged DNA bases. Bacterial Lhr proteins are well-characterized DNA repair helicases that are fused to additional 600-700 amino acids of unknown function, but with structural homology to SecB chaperones and AlkZ DNA glycosylases. Here, we identify that Escherichia coli Lhr is a uracil-DNA…

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