A metabolite specific 3D stack-of-spirals bSSFP sequence for improved bicarbonate imaging in hyperpolarized [1-13C]Pyruvate MRI.

Xiaoxi Liu¹, Shuyu Tang², Di Cui¹, Robert A Bok¹, Hsin-Yu Chen¹, Jeremy W Gordon¹, Zhen J Wang¹, Peder E Z Larson³

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.

²Vista.ai Inc., Los Altos, CA, USA.

³Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, San Francisco, CA, USA. Electronic address: peder.larson@ucsf.edu.

PubMed PMC DOI PDF

Abstract

13C-bicarbonate is a crucial measure of pyruvate oxidation and TCA cycle flux, but is challenging to measure due to its relatively low concentration and thus will greatly benefit from improved signal-to-noise ratio (SNR). To address this, we developed and investigated the feasibility of a 3D stack-of-spirals metabolite-specific balanced steady-state free precession (MS-bSSFP) sequence for improvin…

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