Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids.

Philip A Verhoef^1,2, Alexandra B Spicer³, Carlos Lopez-Espina⁴, Akhil Bhargava⁴, Lee Schmalz⁴, Matthew D Sims⁵, Ashok V Palagiri⁶, Karthik V Iyer⁷, Matthew J Crisp⁷, Alexandra Halalau⁵, Nicholas Maddens⁵, Falgun Gosai⁸, Anwaruddin Syed⁸, Saleem Azad⁷, Aimee Espinosa⁵, Francisco Davila⁵, Hugo Davila⁵, Neil R Evans⁸, Scott Smith⁵, Bobby Reddy⁴, Pratik Sinha⁹, Matthew M Churpek³

¹Hawaii Permanente Medical Group, Honolulu, HI.

²Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI.

³Department of Medicine, University of Wisconsin-Madison, Madison, WI.

⁴Prenosis Inc., Chicago, IL.

⁵Beaumont Health System, Royal Oak, MI.

⁶Mercy Hospital, St. Louis, MO.

⁷Mercy Hospital, Jefferson, MO.

⁸OSF Saint Francis Medical Center, Peoria, IL.

⁹Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO.

PubMed PMC DOI PDF

Abstract

OBJECTIVES: To identify and validate novel COVID-19 subphenotypes with potential heterogenous treatment effects (HTEs) using electronic health record (EHR) data and 33 unique biomarkers. DESIGN: Retrospective cohort study of adults presenting for acute care, with analysis of biomarkers from residual blood collected during routine clinical care. Latent profile analysis (LPA) of biomarker and EHR d…

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Mentioned Companies

Prenosis
affiliation

NIH Funding

Grant #10891625
Data Driven Strategies for Substance Misuse Identification in Hospitalized Patients
UNIVERSITY OF WISCONSIN-MADISON
$707,649 (FY2024)
Grant #11290398
Sepsis Early Prediction and Subphenotype Illumination Study (SEPSIS)
UNIVERSITY OF WISCONSIN-MADISON
$388,750 (FY2026)

Other Funding

NIDDK NIH HHS(R01 DK126933)
United States
NIGMS NIH HHS(R35 GM142992)
United States
NIGMS NIH HHS(R35 GM145330)
United States
NIA NIH HHS(R21 AG068720)
United States
NIGMS NIH HHS(R01 GM123193)
United States
NIDDK NIH HHS(R21 DK113420)
United States
NIDA NIH HHS(R01 DA051464)
United States
NHLBI NIH HHS(R01 HL157262)
United States

MeSH Terms

Adult0Humans0COVID-19*Retrospective Studies0Glucocorticoids0Biomarkers0Hospital Mortality0

Article Info

PMID: 37378460
PMCID: PMC11796285
DOI: 10.1097/CCM.0000000000005983

How to Cite

Verhoef PA et al. Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids. Crit Care Med2023;51(12):1697-1705. doi:10.1097/CCM.0000000000005983

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