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Peer-Reviewed Publication
Genes (Basel)2023;14(6)June 8, 2023Journal Article

The Reversion of the Epigenetic Signature of Coronary Heart Disease in Response to Smoking Cessation.

Robert Philibert1,2,3, Joanna Moody1, Willem Philibert1, Meeshanthini V Dogan2,3, Eric A Hoffman3,4
1Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
2Cardio Diagnostics Inc., Chicago, IL 60642, USA.
3Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA.
4Department of Radiology, University of Iowa, Iowa City, IA 52242, USA.
PubMed PMC DOI PDF

Abstract

Coronary heart disease (CHD) is the leading cause of death worldwide. However, current diagnostic tools for CHD, such as coronary computed tomography angiography (CCTA), are poorly suited for monitoring treatment response. Recently, we have introduced an artificial-intelligence-guided integrated genetic-epigenetic test for CHD whose core consists of six assays that determine methylation in pathway…

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