Health AI Central
Peer-Reviewed Publication
Mod Pathol2023;36(3):100033.March 1, 2023Journal Article

Noninferiority of Artificial Intelligence-Assisted Analysis of Ki-67 and Estrogen/Progesterone Receptor in Breast Cancer Routine Diagnostics.

Niklas Abele1, Katharina Tiemann2, Till Krech3, Axel Wellmann4, Christian Schaaf5, Florian Länger6, Anja Peters7, Andreas Donner8, Felix Keil9, Khalid Daifalla10, Marina Mackens2, Andreas Mamilos9, Evgeny Minin11, Michel Krümmelbein2, Linda Krause12, Maria Stark12, Antonia Zapf12, Marc Päpper10, Arndt Hartmann13, Tobias Lang10
1Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut für Pathologie, Erlangen, Germany. Electronic address: niklas.abele@uk-erlangen.de.
2Institute of Hematopathology Hamburg, Hamburg, Germany.
3Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany.
4Institute of Pathology Celle, Celle, Germany.
5Department of Internal Medicine II, Klinikum rechts der Isar of the TU Munich, Munich, Germany.
6Institut für Pathologie, Medizinische Hochschule Hannover, Hannover, Germany.
7Institut für Pathologie, Städtisches Klinikum Lüneburg gGmbH, Lüneburg, Germany.
8Zentrum für Pathologie, Zytologie und Molekularpathologie Neuss, Neuss, Germany.
9Institute of Pathology, University of Regensburg, Regensburg, Germany.
10Mindpeak, Hamburg, Germany.
11Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany.
12Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
13Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut für Pathologie, Erlangen, Germany.
PubMed DOI

Abstract

Image analysis assistance with artificial intelligence (AI) has become one of the great promises over recent years in pathology, with many scientific studies being published each year. Nonetheless, and perhaps surprisingly, only few image AI systems are already in routine clinical use. A major reason for this is the missing validation of the robustness of many AI systems: beyond a narrow context,…

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